KMID : 0361020060490121165
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Korean Journal of Otolaryngology - Head and Neck Surgery 2006 Volume.49 No. 12 p.1165 ~ p.1171
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The Effect of Genotype of NAT2, TNF-¥á and TGF-¥â Genes on Allergic Rhinitis in Korea
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Park Yoon-Keun
Kang Jong-Won Kim Yong-Dae Lee Chul-Ho Eom Sang-Yong Kim Heon
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Abstract
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Background and Objectives : The inflammatory reaction is affected by the genotype or phenotype of genes related with inflammation modulating cytokines and allergen metabolizing enzyme. This study was performed to investigate the relationship between N-acetyl transferase 2 (NAT2), tumor necrosis factor-alpha(TNF-alpha), transforming growth factor-beta(TGF-beta) and the allergic rhinitis in Korea.
Subjects and Method : One hundred forty five allergic rhinitis patients and 167 controls were included. Venous blood samples were collected and the genotypes were analyzed by PCR technique. NAT2 phenotypes were designated as ¡¯high¡¯, ¡¯medium¡¯ and ¡¯low¡¯ by known genotype-phenotype relationship. TNF-alpha genotypes were classified as ¡¯A/A¡¯, ¡¯A/G¡¯ and ¡¯G/G¡¯. TGF-beta genotype was classified as ¡¯Arg/Arg¡¯, ¡¯Arg/Pro¡¯ and ¡¯Pro/Pro¡¯. These data were analyzed by SAS for windows ver 8.02.
Results : The phenotype of NAT2 and genotype of TGF-beta showed no significant effect on allergic rhinitis. G/G or G/A genotype of TNF-alpha significantly increases the risk of allergic rhinitis. High activity phenotype of NAT2 showed higher level of total serum IgE.
Conclusion : Genetic factors including TGF-beta are important in the development of allergic rhinitis in Korea. NAT2 phenotype affect allergic reaction.
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KEYWORD
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Allergic Rhinitis, NAT2, TNF-¥á, TGF-¥â
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